主讲：美国马里兰大学 Yu Chen, Associate Professor
专家简介：Dr. Yu Chen received his BS in Physics from Peking University in 1997 and his PhD in Bioengineering from the University of Pennsylvania in 2003. From 2003-2007, he pursued his postdoctoral training at MIT. He became an Assistant Professor of the Fischell Department of Bioengineering at the University of Maryland in College Park in 2007 and became an Associate Professor since 2014. He has mentored 8 PhD students and 7 postdoctoral fellows. He received Teaching Excellence Award from the Fischell Department of Bioengineering of the University of Maryland in 2011, and the National Science Foundation (NSF) CAREER Award in 2012. Dr. Chen has published 1 book, 16 book chapters, and 93 peer-reviewed journal publications. He has been an associate editor of Medical Physics, a guest editor of IEEE Journal of Selected Topics on Quantum Electronics, Journal of Innovative Optical Health Sciences, Neurophotonics, and an Editorial Board member of Scientific Reports. He is a member of IEEE, SPIE, and a senior member of Optical Society of America (OSA). He has served as conference program co-chair and general co-chair for OSA Conference on Lasers and Electro-Optics (CLEO): Applications and Technologies.
报告摘要：Optical Coherence Tomography (OCT) is an established medical imaging technology which is analogous to ultrasound imaging but has significantly higher resolution (~10 m) to enable 3D imaging of tissue microstructures in situ and in real-time with a penetration depth of ~1-2 mm. OCT can be extended to functional imaging modalities such as Doppler OCT (DOCT) for blood flow detection and polarization-sensitive OCT (PS-OCT) for detection of tissue birefringence. We have developed a forwarding-imaging needle-type OCT probe for avoiding the hemorrhage and guiding neurosurgical interventions. The needle probe has a thin diameter of 0.7 mm. The feasibility of vessel detection and neurosurgical guidance were demonstrated on sheep brain in vivo and human brain ex vivo. In addition, we further reduced the probe size to 0.3 mm using an optical Doppler sensing (ODS) fiber probe that can integrate with microelectrode recording (MER) to detect the blood vessels lying ahead to improve the safety of this procedure. We further combine high-resolution OCT with large-field-of-view magnetic resonance imaging (MRI) to provide multi-scale imaging.