时间：2025年10月10日下午 4: 00
地点：理工楼18号楼-307学术报告厅
主讲：黄志伟，博士/教授，新加坡国立大学
主办：光电与信息工程学院，医学光电科学与技术教育部重点实验室，福建省光子技术重点实验室
专家简介
Prof. Zhiwei Huang is Director of Optical Bioimaging Laboratory in the Department of Biomedical Engineering, College of Design and Engineering at the National University of Singapore (NUS). He is an internationally renowned expert in biomedical optics, biophotonics and microscopy imaging. His major research areas are in the fields of biomedical optics, biophotonics, advanced microscopy, Raman spectroscopy and imaging, particularly centering on the development of label-free super-resolution microscopy and nonlinear optical microscopy imaging techniques (e.g., coherent Raman scattering microscopy, multiphoton microscopy) and their applications in biomolecular imaging, as well as the development of novel fiberoptic Raman spectroscopy and endoscopic imaging, enabling early diagnosis and detection of epithelial precancer and cancer at endoscopy. He pioneered in Raman endoscopy and labelfree super-resolution bioimaging technologies, and published over 150 peer-reviewed articles in leading journals (e.g., Nature Photonics, Light: Science & Applications, Gastroenterology), and delivered over 100 plenary/keynote/invited lectures worldwide. He has filed over 20 US patents with 10 licensed for commercialization. His IMDX technique invented was ranked No.1 among the top 10 medical devices listed in Medica, Germany. He is the conference chair for the SPIE-Photonics West-BiOS conference on Biomedical Vibrational Spectroscopy: Advances in Research and Industry, San Francisco, California, the United States. He is also the conference Chair for the OPTICA/SPIE-European Conferences on Biomedical Optics (ECBO) on Translational Biophotonics: Diagnostics and Therapeutics, Munich, Germany. He is elective Fellow of SPIE- the international society for optics and photonics.
讲座简介
In this talk, I will introduce our very recently developed innovative time-domain stimulated Raman scattering (SRS) tomography (TD-SRST) technique for rapid dynamic and functional 3D imaging of live cells and tissue with biomolecular specificity. In TD-SRST, the novel Bessel excitation light bullets are generated to enhance the imaging penetration depth, while the time of-flight resolved approach based on the generation and control of ultraslow counterpropagating Bessel light bullets with angular dispersion enable us to retrieve the depth information in time-domain without the need of mechanical z-scanning for label-free SRST 3D imaging. SRST provides over 3-fold improvement in penetration depth in highly scattering media as compared to the conventional point-scan SRS microscopy. Real-time 3D dynamic and metabolic functional imaging of live cells and tissues can be achieved using TD-SRST technique. Further, the spatio-temporal multiplex can also be incorporated into TD-SRST to significantly advance label-free biomolecular 3D imaging of live tissue and cells in biological and biomedical systems.