时间：2016年9月26日（周一）下午16：00-17：00
地点：仓山校区光电与信息工程学院四层学术报告厅
主讲：加拿大University Health Network ，Margarete Akens 研究员
主办：光电与信息工程学院
专家简介：Dr. Margarete Akens is a Scientist at the Techna Institute and an Assistant Professor at the Department of Surgery and a Faculty member of the Spine Program at the University of Toronto. She received her PhD from the Faculty of Veterinary Medicine at the University in Zurich, Switzerland, in 2002. Her research interests include bone related cancers and bone repair with focus on the development of innovative treatment options. She has extensive experience working with pre-clinical bone cancer models and studying the effect of photodynamic therapy on both cancer cells and bone. Additionally she will lead the emerging Comparative Oncology Program at STTARR. Cancer occurs naturally in animals with a similar frequency as in humans, but due to the shorter life span everything happens faster. This program focus on collaboration between Veterinarians and Physicians to accelerate the knowledge about cancer biology and clinical care.
报告摘要：Photodynamic therapy has been successfully applied to various cancers. We investigated PDT treatment of bone metastases in the spine secondary to breast cancer in a rat model, and we have been able to shown that PDT is able to destroy tumour cells within the vertebrae. This encouraging results let to an ongoing first clinical trial (Phase 1) examining the use of PDT on breast cancer vertebral metastases. The most surprising result from the preclinical work in the rat model was the positive impact of PDT on bone. PDT was shown to improve bone strength, stiffness and architecture in healthy and metastatically involved vertebrae. The positive results found in bone tissue secondary to PDT treatment led me to the hypothesis that PDT may be beneficial in the treatment of fractures at risk for delayed healing. I investigated the healing of critically sized defects in a rat model. Results have yielded statistically significant improvements in both bone quality and fracture gap reduction in critically sized femoral defects between PDT treated and control groups and warrant further investigation.